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Patch Clamp Amplifier

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For any researcher who desires manual user control through knobs and dials, while at the same time, longs for some degree of computer communication and automatic control, HEKA is excited to release the EPC 800 USB. This amplifier is truly a unique hybrid patch-clamp amplifier with its design and feature-set primarily based upon the manually controlled EPC 8. The EPC 800 USB can be controlled with any data acquisition interface and can be supported, not only by HEKA software, but also with third-party data acquisition programs.

The EPC 800 USB amplifier comes with a Red Star headstage as a standard. It is also possible to order the instrument with the S-Probe instead.

Read more Operating Modes of the EPC 800 USB

The EPC 800 USB can be operated in three modes: Telegraphing Local, Local and Remote. The decision of which mode to use not only depends upon user preference of whether or not to have the functionality to turn knobs and switches, but also upon what data acquisition software and interface the EPC 800 USB is used with.

1. Telegraphing Local:
  • Rear panel telegraphing outputs for Gain, Filter Bandwidth, Amplifier Mode and C-Slow allows third-party acquisition software (e.g. IGOR, Labview, pCLAMP) to read the status of these amplifier settings while recording data.
  • Manual control by use of the knobs and switches on the front panel.

2. Local:
3. Remote:
  • Full support of all amplifier functions by HEKA's PATCHMASTER acquisition software.
  • USB 2.0 communication. Please note that this is a full speed (12 Mbit/second) connection.
  • Front panel knobs and switches of the amplifier are inactive, with the exception of the LCD multi-position switch.
  • Can be used with HEKA's PATCHMASTER software or EPCMASTER software in combination with custom software and appropriate interface.

Improvements compared to EPC 8:
  • Telegraphing outputs for Gain, Bandwidth, Mode & C-Slow
  • Automatic Vp-Offset, C-Fast & C-Slow compensation with the simple push of a button
  • Improved current monitor filters
  • USB 2.0 communication for software control of all amplifier functions
  • Low Frequency Voltage Clamp Mode (LFVC)
  • CC+Bridge Mode
  • Improved RS Comp Range

  • Dimensions (D x W x H): 90 x 17 x 14.5 mm / 3.54 x 0.67 x 0.57 inch, without connector
  • Improved noise performance in the important 1 - 10 kHz band
  • Three feedback resistors for three gain ranges, switchable during the measurement
  • Optimized for single-channel and whole-cell recordings
  • Quiet enough for the most demanding single-channel applications


T. B. Franklin, B. A. Silva, Z. Perova, L. Marrone, M. E. Masferrer, Y. Zhan, A. Kaplan, L. Greetham, V. Verrechia, A. Halman, S. Pagella, A. L. Vyssotski, A. Illarionova, V. Grinevich, T. Branco, C. T. Gross (2017). "Prefrontal cortical control of a brainstem social behavior circuit." Nature Neuroscience 20: 260-270.