These include automatic switching (e.g, switching between the settings for establishing a seal or those for single channel recording) and also the automatic adjustment of capacitance transients cancellation and series resistance compensation. In fact, digital control of every adjustable parameter in the amplifier circuitry is implemented, including the calibration adjustments.

The EPC 10 USB is a complete data acquisition system, which can be controlled with HEKA's PATCHMASTER or PATCHMASTER NEXT software. A DLL (dynamic link library) is available to allow access of the system from a custom written application. The EPC 10 USB patch clamp amplifier, combined with a computer and PATCHMASTER or PATCHMASTER NEXT software is equivalent to a fully equipped setup, which includes a patch clamp amplifier, a digital storage oscilloscope, a variable analog filter, a sophisticated pulse generator, and a fully featured data acquisition and analysis system.

The EPC 10 USB amplifier comes with a Red Star headstage as a standard. It is also possible to order the instrument with the S-Probe.

• Low noise single channel recordings
• Low noise whole-cell patch clamp recordings: voltage clamp and current clamp / LFVC
• Loose patch recordings
• Intracellular voltage recordings with high resistance electrodes
• Field potential recordings with metal microelectrodes
• Recording from artificial membranes (Bilayer recordings)
• Study of Long Term Potentiation (LTP) and Long Term Depression (LTD)
• Study of Exocytosis/Endocytosis or Synaptic transmission by:
  • Measurement of whole-cell membrane capacitance (PATCHMASTER)
  • Measurement of on-cell membrane capacitance (PATCHMASTER)
  • Detection of released substances (amperometry with e.g. carbon fibre electrodes
  • Detection of releases substances under a patch (patch amperometry)

• Dimensions (D x W x H): 90 x 17 x 14.5 mm / 3.54 x 0.67 x 0.57 inch, without connector
• Improved noise performance in the important 1 - 10 kHz band
• Three feedback resistors for three gain ranges, switchable during the measurement
• Optimized for single-channel and whole-cell recordings
• Quiet enough for the most demanding single-channel applications
• Retrofittable on older EPC 10 Amplifiers

2017

A. S. Axelsson, T. Mahdi, H. A. Nenonen, T. Singh, S. Hänzelmann, A. Wendt, A. Bagge, T. M. Reinbothe, J. Millstein, X. Yang, B. Zhang, E. G. Gusmao, L. Shu, M. Szabat, Y. Tang, J. Wang, S. Salö, L. Eliasson, I. Artner, M. Fex, J. D. Johnson, C. B. Wollheim, J. M. J. Derry, B. Mecham, P. Spégel, H. Mulder, I. G. Costa, E. Zhang and A. H. Rosengren (2017). "Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes." Nature Communications 8: 15652.

S. Bahari-Javan, H. Varbanov, R. Halder, E. Benito, L. Kaurani, S. Burkhardt, H. Anderson-Schmidt, I. Anghelescu, M. Budde, R. M. Stilling, J. Costa, J. Medina, D. E. Dietrich, C. Figge, H. Folkerts, K. Gade, U. Heilbronner, M. Koller, C. Konrad, S. Y. Nussbeck, H. Scherk, C. Spitzer, S. Stierl, J. Stöckel, A. Thiel, M. von Hagen, J. Zimmermann, A. Zitzelsberger, S. Schulz, A. Schmitt, I. Delalle, P. Falkai, T. G. Schulze, A. Dityatev, F. Sananbenesi and A. Fischer (2017). "HDAC1 links early life stress to schizophrenia-like phenotypes." Proceedings of the National Academy of Sciences 114(23): E4686-E4694.

A. Brechet, R. Buchert, J. Schwenk, S. Boudkkazi, G. Zolles, K. Siquier-Pernet, I. Schaber, W. Bildl, A. Saadi, C. Bole-Feysot, P. Nitschke, A. Reis, H. Sticht, N. Al-Sanna´a, A. Rolfs, A. Kulik, U. Schulte, L. Colleaux, R. Abou Jamra and B. Fakler (2017). "AMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability." Nature Communications 8: 15910.

S. Cains, C. Blomeley, M. Kollo, R. Rácz and D. Burdakov (2017). "Agrp neuron activity is required for alcohol-induced overeating." Nature Communications 8: 14014.

G. Chen, Y. H. Kim, H. Li, H. Luo, D.-L. Liu, Z.-J. Zhang, M. Lay, W. Chang, Y.-Q. Zhang and R.-R. Ji (2017). "PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron activity via PD-1." Nature Neuroscience 20(7): 917-926.

C. E. Constantin, C. S. Müller, M. G. Leitner, W. Bildl, U. Schulte, D. Oliver and B. Fakler (2017). "Identification of Cav2-PKCß and Cav2-NOS1 complexes as entities for ultrafast electrochemical coupling." Proceedings of the National Academy of Sciences 114(22): 5702-5712.

J. J. Fink, T. M. Robinson, N. D. Germain, C. L. Sirois, K. A. Bolduc, A. J. Ward, F. Rigo, S. J. Chamberlain and E. S. Levine (2017). "Disrupted neuronal maturation in Angelman syndrome-derived induced pluripotent stem cells." Nature Communications 8: 15038.

R. Fliegert, A. Bauche, A.-M. Wolf Perez, J. M. Watt, M. D. Rozewitz, R. Winzer, M. Janus, F. Gu, A. Rosche, A. Harneit, M. Flato, C. Moreau, T. Kirchberger, V. Wolters, B. V. L. Potter and A. H. Guse (2017). "2[prime]-Deoxyadenosine 5[prime]-diphosphoribose is an endogenous TRPM2 superagonist." Nature Chemical Biology (advance online publication).

M. Harkat, L. Peverini, A. H. Cerdan, K. Dunning, J. Beudez, A. Martz, N. Calimet, A. Specht, M. Cecchini, T. Chataigneau and T. Grutter (2017). "On the permeation of large organic cations through the pore of ATP-gated P2X receptors." Proceedings of the National Academy of Sciences 114(19): E3786-E3795.

I. J. Jang, A. J. Davies, N. Akimoto, S. K. Back, P. R. Lee, H. S. Na, H. Furue, S. J. Jung, Y. H. Kim and S. B. Oh (2017). "Acute inflammation reveals GABAA receptor-mediated nociception in mouse dorsal root ganglion neurons via PGE2 receptor 4 signaling." Physiological Reports 5(8).

M.-H. Jeong, H.-J. Kim, J.-H. Pyun, K.-S. Choi, D. I. Lee, S. Solhjoo, B. O'Rourke, G. F. Tomaselli, D. S. Jeong, H. Cho and J.-S. Kang (2017). "Cdon deficiency causes cardiac remodeling through hyperactivation of WNT/ß-catenin signaling." Proceedings of the National Academy of Sciences 114(8): E1345-E1354.

S. L. Johnson, J. Olt, S. Cho, H. von Gersdorff and W. Marcotti (2017). "The Coupling between Ca2+ Channels and the Exocytotic Ca2+ Sensor at Hair Cell Ribbon Synapses Varies Tonotopically along the Mature Cochlea." Journal of Neuroscience 37(9): 2471-2484.

C.-H. Liu, Z. Gong, Z.-L. Liang, Z.-X. Liu, F. Yang, Y.-J. Sun, M.-L. Ma, Y.-J. Wang, C.-R. Ji, Y.-H. Wang, M.-J. Wang, F.-A. Cui, A. Lin, W.-S. Zheng, D.-F. He, C.-x. Qu, P. Xiao, C.-Y. Liu, A. R. B. Thomsen, T. Joseph Cahill Iii, A. W. Kahsai, F. Yi, K.-H. Xiao, T. Xue, Z. Zhou, X. Yu and J.-P. Sun (2017). "Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling." Nature Communications 8: 14335.

M. M. Picher, A. Gehrt, S. Meese, A. Ivanovic, F. Predoehl, S. Jung, I. Schrauwen, A. G. Dragonetti, R. Colombo, G. Van Camp, N. Strenzke and T. Moser (2017). "Ca2+-binding protein 2 inhibits Ca2+-channel inactivation in mouse inner hair cells." Proceedings of the National Academy of Sciences 114(9): E1717-E1726.

A. Ramot, Z. Jiang, J.-B. Tian, T. Nahum, Y. Kuperman, N. Justice and A. Chen (2017). "Hypothalamic CRFR1 is essential for HPA axis regulation following chronic stress." Nature Neuroscience 20(3): 385-388.

L. Romani, V. Oikonomou, S. Moretti, R. G. Iannitti, M. C. D'Adamo, V. R. Villella, M. Pariano, L. Sforna, M. Borghi, M. M. Bellet, F. Fallarino, M. T. Pallotta, G. Servillo, E. Ferrari, P. Puccetti, G. Kroemer, M. Pessia, L. Maiuri, A. L. Goldstein and E. Garaci (2017). "Thymosin [alpha]1 represents a potential potent single-molecule-based therapy for cystic fibrosis." Nature Medicine 23(5): 590-600.

N. Romanò, A. Guillou, D. J. Hodson, A. O. Martin and P. Mollard (2017). "Multiple-scale neuroendocrine signals connect brain and pituitary hormone rhythms." Proceedings of the National Academy of Sciences 114(9): 2379-2382.

W. Shen, C. Nan, P. T. Nelson, H. Ripps and M. M. Slaughter (2017). "GABAB receptor attenuation of GABAA currents in neurons of the mammalian central nervous system." Physiological Reports 5(6).

A. Sigler, W. C. Oh, C. Imig, B. Altas, H. Kawabe, B. H. Cooper, H.-B. Kwon, J.-S. Rhee and N. Brose (2017). "Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release." Neuron 94(2): 304-311.e304.

P. Somasundaram, G. R. Wyrick, D. C. Fernandez, A. Ghahari, C. M. Pinhal, M. Simmonds Richardson, A. C. Rupp, L. Cui, Z. Wu, R. L. Brown, T. C. Badea, S. Hattar and P. R. Robinson (2017). "C-terminal phosphorylation regulates the kinetics of a subset of melanopsin-mediated behaviors in mice." Proceedings of the National Academy of Sciences 114(10): 2741-2746.

A. Stange-Marten, A. L. Nabel, J. L. Sinclair, M. Fischl, O. Alexandrova, H. Wohlfrom, C. Kopp-Scheinpflug, M. Pecka and B. Grothe (2017). "Input timing for spatial processing is precisely tuned via constant synaptic delays and myelination patterns in the auditory brainstem." Proceedings of the National Academy of Sciences 114(24): E4851-E4858.

L. Tao, L. Peng, R. P. A. Berntsson, S. M. Liu, S. Park, F. Yu, C. Boone, S. Palan, M. Beard, P.-E. Chabrier, P. Stenmark, J. Krupp and M. Dong (2017). "Engineered botulinum neurotoxin B with improved efficacy for targeting human receptors." Nature Communications 8(1): 53.

C. Wetzel, S. Pifferi, C. Picci, C. Gok, D. Hoffmann, K. K. Bali, A. Lampe, L. Lapatsina, R. Fleischer, E. S. J. Smith, V. Begay, M. Moroni, L. Estebanez, J. Kuhnemund, J. Walcher, E. Specker, M. Neuenschwander, J. P. von Kries, V. Haucke, R. Kuner, J. F. A. Poulet, J. Schmoranzer, K. Poole and G. R. Lewin (2017). "Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity." Nature Neuroscience 20(2): 209-218.

Wu, Z., N. Grillet, B. Zhao, C. Cunningham, S. Harkins-Perry, B. Coste, S. Ranade, N. Zebarjadi, M. Beurg, R. Fettiplace, A. Patapoutian and U. Muller (2017). "Mechanosensory hair cells express two molecularly distinct mechanotransduction channels." Nature Neuroscience 20(1): 24-33.

A. J. Yiu, C.-L. Ibeh, S. K. Roy and B. C. Bandyopadhyay (2017). "Melamine induces Ca2+-sensing receptor activation and elicits apoptosis in proximal tubular cells." American Journal of Physiology - Cell Physiology 313(1): C27-C41.

X. Zhang and A. N. van den Pol (2017). "Rapid binge-like eating and body weight gain driven by zona incerta GABA neuron activation." Science 356(6340): 853-859.

L. Zhou, J. McInnes, K. Wierda, M. Holt, A. G. Herrmann, R. J. Jackson, Y.-C. Wang, J. Swerts, J. Beyens, K. Miskiewicz, S. Vilain, I. Dewachter, D. Moechars, B. De Strooper, T. L. Spires-Jones, J. De Wit and P. Verstreken (2017). "Tau association with synaptic vesicles causes presynaptic dysfunction." Nature Communications 8: 15295.